反应详情

A mixture of 2,6-dihydroxyacetophenone (5.35 gm; 35.0 mmoles), potassium carbonate (4.83 gm; 35.0 mmoles), and p methoxyphenacylbromide (8.05 gm; 35.0 mmoles) in acetone (150 mL) was refluxed for a period of 22 hours. The reaction mixture was cooled, filtered through Celite, and concentrated in vacuo. The residue was dissolved in methylene chloride and washed with IN sodium hydroxide. The aqueous phase was then acidified with 20% citric acid. The solid was filtered, washed with water, and air dried to yield 6.5 gm (65%) of 2-(p-methoxybenzoyl)-3-methyl-4-hydroxybenzofuran, mp. 192°-195° C.

1. temperaturewas refluxed for a period of 22 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered through Celite
4. concentrationconcentrated in vacuo
5. dissolutionThe residue was dissolved in methylene chloride
6. washwashed with IN sodium hydroxide
7. filtrationThe solid was filtered
8. washwashed with water, and air
9. customdried