Aluminum(III) Chloride → 2,3-Difluoro-4-hydroxybenzonitrile

HRID 1534268Notes

Reaction equation

HRID 1534268 reaction equation
C([O:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[C:6]([F:12])[C:5]=1[F:13])C.[Cl-].[Al+3].[Cl-].[Cl-]>C1(C)C=CC=CC=1>[C:8]([C:7]1[CH:10]=[CH:11][C:4]([OH:3])=[C:5]([F:13])[C:6]=1[F:12])#[N:9]

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 144956264-Ethoxy-2,3-difluorobenzonitrile

Product 1

HCID 27369782,3-Difluoro-4-hydroxybenzonitrile

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 0.1 mol of 4-ethoxy-2,3-difluoro benzonitrile in 100 ml of toluene is slowly added dropwise at room temperature in the course of 30 minutes to a solution of 0.1 mol of aluminium(III) chloride in 100 ml of toluene. The mixture is subsequently heated to boiling for 5 hours and worked up as customary after cooling, m.p.: 145° C.

Workup

  1. temperatureThe mixture is subsequently heated
  2. temperatureafter cooling

Sources & evidence

ORD record
ord-37ba483e93304af2bc653087b067a85a
Source dataset
uspto-grants-1992_02
Patent number
US05087764

Reaction notes

Loading…