関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Oxygen | HCID 977 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 2-tert-Butyl-4-methylphenol | HCID 17004 | — |
| 触媒 | Hydrogen Bromide | HCID 260 | — |
| 触媒 | Cobalt diacetate | HCID 6277 | — |
| 触媒 | Manganese dibromide | HCID 6432071 | — |
| 生成物 | 4-(Acetyloxy)-3-tert-butylbenzoic acid | HCID 18007736 | 84.4% |
反応手順
A mixture of 82.0 g of 2-tert-butyl-4-methylphenol, 140.0 g of acetic anhydride and 3.0 g of hydrobromic acid (48%) is heated at 90° C. for 1 hour. 280.0 g of acetic acid, 2.5 g of cobalt(II) acetate (tetrahydrate) and 2.5 g of manganese(II) bromide (tetrahydrate) are added, and oxygen (30 ml/min) is passed through the solution at 110° C. The acetic acid is partially removed by applying a vacuum. The reaction mixture which remains is poured into 500 ml of water and filtered, giving 99.5 g (84%) of the product in the form of colourless crystals having a melting point of from 180° to 182° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05089050 |
|---|
| 出典データセット | uspto-grants-1992_02 |
|---|
| ORD ID | ord-0fce5456ce9c480881f62c4a616f14c0 |
|---|
| 出典メモ | uspto-grants-1992_02 |
|---|
