関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 11-Bromoundecyl acetate | HCID 5016162 | — |
| 反応物 | Malonic acid ethyl ester dimethylamide | HCID 86745466 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 11-Acetoxyundecane malonic acid ethyl ester dimethylamide | HCID 86745465 | 79.7% |
反応手順
A suspension of 0.6 g of sodium hydride and 3 g of malonic acid ethyl ester dimethylamide in 30 ml of dimethylformamide is stirred for an hour at 22° C., mixed with 6.9 g of 1-acetoxy-11-bromoundecane and stirred for 16 hours at 50° C. Then the reaction mixture is stirred in 200 ml of ice water, extracted with ethyl acetate, the organic phase is dried on sodium sulfate and concentrated by evaporation in vacuum. Thus, 5.3 g of 11-acetoxyundecane malonic acid ethyl ester dimethylamide is obtained as light-yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05089175 |
|---|
| 出典データセット | uspto-grants-1992_02 |
|---|
| ORD ID | ord-ad44622a941143c684f47fc172f6d028 |
|---|
| 出典メモ | uspto-grants-1992_02 |
|---|
