反应详情

Ethyl 2-butyryl-3-(2-carbomethoxyphenylamino)acrylate (8.63 g, 27.0 mmol) was added to boiling diphenyl ether (40 ml), and heated at reflux for 1 hour. On cooling, methyl 3-butyryl-4(1H)-quinolone-8-carboxylate (4.06 g, 55%) crystallised and was filtered off and washed with ether, m.p. 151-153°.

1. temperatureheated
2. temperatureat reflux for 1 hour
3. temperatureOn cooling
4. custommethyl 3-butyryl-4(1H)-quinolone-8-carboxylate (4.06 g, 55%) crystallised
5. filtrationwas filtered off
6. washwashed with ether, m.p. 151-153°