HCID 178450489, Verbindung → methyl 3-butyryl-4(1H)-quinolone-8-carboxylate

HRID 1534362Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1534362
[C:1]([C:6](=[CH:12][NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:20]([O:22][CH3:23])=[O:21])[C:7]([O:9]CC)=O)(=[O:5])[CH2:2][CH2:3][CH3:4]>C1(OC2C=CC=CC=2)C=CC=CC=1>[C:1]([C:6]1[C:7](=[O:9])[C:19]2[C:14](=[C:15]([C:20]([O:22][CH3:23])=[O:21])[CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

Komponenten

3

Edukt 1

HCID 178450489HCID 178450489, Verbindung

Produkt 1

HCID 10107336methyl 3-butyryl-4(1H)-quinolone-8-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7583Diphenyl EtherLösungsmittel

Versuchsvorschrift

Ethyl 2-butyryl-3-(2-carbomethoxyphenylamino)acrylate (8.63 g, 27.0 mmol) was added to boiling diphenyl ether (40 ml), and heated at reflux for 1 hour. On cooling, methyl 3-butyryl-4(1H)-quinolone-8-carboxylate (4.06 g, 55%) crystallised and was filtered off and washed with ether, m.p. 151-153°.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 1 hour
  3. temperatureOn cooling
  4. custommethyl 3-butyryl-4(1H)-quinolone-8-carboxylate (4.06 g, 55%) crystallised
  5. filtrationwas filtered off
  6. washwashed with ether, m.p. 151-153°

Quellen und Nachweise

ORD-Eintrag
ord-8d8d9b7e12a44fe6955e3b8b660c3298
Quelldatensatz
uspto-grants-1992_02
Patentnummer
US05089498

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