Isopropyl iodide → HCID 9866478, compound

Participants

Reaction Steps

200 mg (0.54 mmol) of penicillide (Ib) in 2 ml of dimethylformamide are stirred under argon at 25° C. for 12 h with 0.5 ml (50 mmol) of isopropyl iodide and 160 mg (1.14 mmol) of anhydrous potassium carbonate. After evaporating in vacuo, the residue is taken up with 1 N aqueous hydrochloric acid and the mixture is exhaustively extracted with diethyl ether. After drying the organic phase, the evaporation residue is chromatographed on silica using petroleum ether/ether =1/1. Fractions which are pure by thin layer chromatography are combined and evaporated.

Provenance & Evidence