Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 11-Hydroxy-3-(1-hydroxy-3-methylbutyl)-4-methoxy-9-methyl-5H,7H-dibenzo[b,g][1,5]dioxocin-5-one | HCID 124213 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 15703817 | HCID 15703817 | — |
Reaction Steps
0.14 ml (1.0 mmol) of triethylamine and 86 μl (1.1 mmol) of methanesulphonyl chloride are added at 0° C. under argon to 150 mg (0.4 mmol) of penicillide (Ib) in 3 ml of methylene chloride and the mixture is stirred at 25° C. for 12 h. Acidifying to pH 2, extracting with methylene chloride, washing, drying and evaporating yields, after chromatography on silica gel Si60 in ether/petroleum ether 2:1, 75 mg (41% of theory) of colorless solid
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05089487 |
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| Source dataset | uspto-grants-1992_02 |
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| ORD ID | ord-2f1f570c44084a02831a9afb1b0ee960 |
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| Source note | uspto-grants-1992_02 |
|---|
