HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 15703835, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 11-Hydroxy-3-(1-hydroxy-3-methylbutyl)-4-methoxy-9-methyl-5H,7H-dibenzo[b,g][1,5]dioxocin-5-one | HCID 124213 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 15703835 | HCID 15703835 | — |
Reaction Steps
200 mg (0.54 mmol) of penicillide (Ib) are heated under reflux for 5 h (exclusion of moisture) in 1 ml of dioxane and 0.38 ml (5.2 mmol) of thionyl chloride. After evaporating in vacuo, the residue is taken up in methylene chloride, and the solution is washed with aqueous bicarbonate, then with water, dried and evaporated. Chromatography on silica gel Si60 in ether/petroleum ether=2:1 yields 187 mg (93% of theory) of colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05089487 |
| Source dataset | uspto-grants-1992_02 |
| ORD ID | ord-766cefe857214b32b21cf5a4b2d1e18c |
| Source note | uspto-grants-1992_02 |