2-(Bromomethyl)quinoline → 2-[1-Methoxy-1-[3-methoxy-4-(quinol-2-ylmethoxy)phenyl]propyl]thiazole

Participants

Reaction Steps

Using a similar procedure to that described in Example 1, 2-bromomethylquinoline was reacted with 2-[1 -(4-hydroxy-3-methoxyphenyl)-1-methoxypropyl]thiazole to give 2-[1-methoxy-1-[3-methoxy-4-(quinol-2-ylmethoxy)phenyl]propyl]thiazole in 52% yield, m.p. 100°-102° C. (recrystallised from a mixture of petroleum ether (b.p. 60°-80° C.) and methylene chloride).

Provenance & Evidence