HCID 15165797, compound → HCID 15165798, compound

HRID 1534441Notes

Reaction equation

HRID 1534441 reaction equation
[Cl:1][C:2]1(Cl)[C:8]([CH3:10])([CH3:9])[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:11].[H][H]>C(O)(=O)C.[Pd]>[Cl:1][CH:2]1[C:8]([CH3:9])([CH3:10])[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:11]

Participants

5

Reactant 2

HCID 15165797HCID 15165797, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15165798HCID 15165798, compoundYield 94.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

3.8 g (0.018 moles) of 3,3-dichloro-4,4-dimethyl-2-oxoperhydroazepine were dissolved in 300 ml of glacial acetic acid and shaked at 40 psi of hydrogen with 1.9 g of 10% Pd/C. When the theoretical amount of hydrogen was consumed the catalyst was filtered off and the filtrate evaporated in vacuo to give 3 g of the title compound sufficiently pure for the following step.

Workup

  1. customWhen the theoretical amount of hydrogen was consumed the catalyst
  2. filtrationwas filtered off
  3. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-c6462ff06de142ecb374922243e22909
Source dataset
uspto-grants-1992_02
Patent number
US05089507

Reaction notes

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