Acetone → HCID 86745480, compound

HRID 1534453Notes

Reaction equation

HRID 1534453 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[Br:5]C(C=O)[CH:7]=[O:8].[CH3:11][C:12](C)=O>>[BrH:5].[NH2:1][C:2]1([CH:7]=[O:8])[NH:4][CH:12]=[CH:11][S:3]1

Participants

4

Reactant 3

HCID 180AcetoneHCID 749452-BromopropanedialHCID 2723790Thiourea

Product 1

HCID 86745480HCID 86745480, compound

Procedure

Thiourea (33 g, 0.44 mol) was added to a solution of 2-bromo-1,3-propanedial (66 g, 0.44 mol) in acetone (1 liter) and the resulting mixture was stirred vigorously under reflux for 1 hour. After cooling to room temperature, the solid product was filtered off and dried to give 2-aminothiazolecarboxaldehyde hydrobromide (85 g) as a yellow solid, m.pt. 126° C.

Workup

  1. temperatureunder reflux for 1 hour
  2. filtrationthe solid product was filtered off
  3. customdried

Sources & evidence

ORD record
ord-e271d4659a3c4d75af73d8ac7e4884db
Source dataset
uspto-grants-1992_02
Patent number
US05089512

Reaction notes

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