Sodium Hydroxide → HCID 10043588, compound

Participants

Reaction Steps

A solution of 3-isobutyryl-4-chloro-8-benzoyloxymethylquinoline (1.84 g, 5 mmol) and 4-fluoro-2-methylaniline (0.78 ml, 7 mmol) in dioxan (25 ml) was heated at reflux for 2 hours, then the solvent evaporated. A solution of sodium hydroxide (0.8 g, 20 mmol) in methanol (50 ml) was added and the mixture stirred at room temperature for 1.5 hours. The resulting precipitate was filtered off and recrystallized from methanol to give (0.48 g, 27%), m.p. 139°-140°.

Provenance & Evidence