Ethanol → Ethyl 6-chloronicotinate
反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11](O)[CH3:12].C1(N=C=NC2CCCCC2)CCCCC1.CN(C1C=CC=CN=1)C>C(Cl)Cl>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH2:11][CH3:12])=[O:7])=[CH:4][N:3]=1参加物
6
実験手順
A mixture of 15.75 g (0.1 mol) 6-chloronicotinic acid, 6.9 g (0.15 mol) ethanol, 22.7 g (0.11 mol) dicyclohexylcarbodiimide and 3.7 g dimethylaminopyridine in 200 ml methylene chloride was heated at reflux for 2 hours. The mixture was allowed to cool, solvent removed in vacuo and residue subjected to flash chromatography to give the title compound as a low-melting white solid.
後処理
- temperaturewas heated
- temperatureat reflux for 2 hours
- temperatureto cool
- customsolvent removed in vacuo and residue
出典と根拠
- ORDレコード
- ord-431b14d6a3284af3939b63139f3b0dc9
- 出典データセット
- uspto-grants-1992_02
- 特許番号
- US05089509
反応ノート
読み込み中…