Pyridine → HCID 54549977, compound

Participants

Reaction Steps

To a mixture of 32.6 mg (0.10 mmole) of 5-hydroxy-8-chloro-11-(4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine and 9.7 )1 (0.12 mmole) of pyridine in a solution of 2 mL of methanol and 1 mL of CH2Cl2 at 0° C. and under a nitrogen atmosphere was added 11.3 )1 (0.12 mmole) of acetic anhydride. After 30 min. the mixture was poured into water which was subsequently adjusted to pH of about 9 with aqueous sodium hydroxide. The mixture was extracted 2× with CH2Cl2. The organic portions were combined, washed once with brine, dried over Na2SO4, filtered, and concentrated in vacuo to yield 31.2 mg of the title compound as a glass.

Provenance & Evidence