Methyl iodide → HCID 22914791, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 500 mg (1.42 mmole) of 8-chloro-11-(1-acetyl-4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine and 175 μl (2.81 mmole) of methyl iodide in 30 mL of toluene was heated at 100° C. for about 19 hours. The reaction mixture was cooled to room temperature and the solvent decanted off. The remaining residue was recrystallized twice from CH2Cl2 /isopropyl ether/hexanes to give 432 mg of the title compound as tan crystals. (m.p. 245°-247° C.).

Provenance & Evidence