Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | HCID 67900985 | HCID 67900985 | — |
| Product | HCID 67900993 | HCID 67900993 | — |
Reaction Steps
A preferred method for halogenation includes subjecting the 2-hydroxycepham to triphenylphosphine in an amount between about 1 and 2 molar equivalents, and iodine in an amount between about 1 and 2 molar equivalents in an inert organic solvent, heating the mixture at approximately 80° C. while stirring the mixture until no starting material is present, thus forming the 2-iodo cepham (IIIA).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05089610 |
|---|
| Source dataset | uspto-grants-1992_02 |
|---|
| ORD ID | ord-b1421fe655784e83880e5cb3e4d2d137 |
|---|
| Source note | uspto-grants-1992_02 |
|---|
