HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Toluenesulfonamide → 1-p-Toluenesulfonyl-3,4-bis(bromomethyl)-3-pyrroline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Toluenesulfonamide | HCID 6269 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,4-Dibromo-2,3-bis(bromomethyl)-2-butene | HCID 35343 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-p-Toluenesulfonyl-3,4-bis(bromomethyl)-3-pyrroline | HCID 19908236 | 61.7% |
Reaction Steps
19 g of tetrakis (bromomethyl)ethylene and 9 g of p-toluene sulfonamide were dissolved in 220 ml of dimethylformamide. 30 g of anhydrous potassium carbonate was added and then stirred at room temperature for 20 hours. Thereafter solvent was removed by vacuum distillation. 50 ml of ethylacetate was added to obtain solid product, and solid product was purified by silica gel column chromatography. 12 g of the title compound was obtained (yield 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05089621 |
| Source dataset | uspto-grants-1992_02 |
| ORD ID | ord-a32000af4d8a4116999b0ef3e6b4868e |
| Source note | uspto-grants-1992_02 |