反应详情

The solution of 0.4 g of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 0.8 g of 3,7-diazabicyclo[3.3.0]oct-1(5)-ene dihydrobromide, and 0.6 ml of 1,8-diazabicyclo[5.4.0]undex-7-ene (DBU) in 40 ml of acetonitrile was refluxed at the reaction temperature of 100° C. for 7 hours. This reaction mixture was kept overnight at the room temperature, and the produced precipitate was filtered and then the residue was washed with ethanol to obtain 0.3 g of the title compound (yield 57%).

1. filtrationthe produced precipitate was filtered
2. washthe residue was washed with ethanol