Thionyl Chloride → 2-(2,2-Difluorocyclopropyl)acetyl chloride

HRID 1534695Notes

Reaction equation

HRID 1534695 reaction equation
[F:1][C:2]1([F:9])[CH2:4][CH:3]1[CH2:5][C:6](O)=[O:7].S(Cl)([Cl:12])=O>>[F:1][C:2]1([F:9])[CH2:4][CH:3]1[CH2:5][C:6]([Cl:12])=[O:7]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 144585032-(2,2-Difluorocyclopropyl)acetic acid

Product 1

HCID 144585042-(2,2-Difluorocyclopropyl)acetyl chloride

Procedure

A mixture of 39.8 g (0.29 mmol) 2,2-difluorocyclopropylacetic acid and 38.5 ml (0.53 mmol) thionyl chloride was heated under reflux for 5 hours. Excess thionyl chloride was distilled and the residue was distilled in vacuo.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. distillationExcess thionyl chloride was distilled
  4. distillationthe residue was distilled in vacuo

Sources & evidence

ORD record
ord-6a49deb1c87f48db9fd8f8515f980d85
Source dataset
uspto-grants-1992_02
Patent number
US05089662

Reaction notes

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