HCID 22842420, compound → HCID 10411587, compound

HRID 1534714Notes

Reaction equation

HRID 1534714 reaction equation
[C:1]([NH:8][C@H:9]([C:17]([NH:19][C:20]1[CH:30]=[C:29]2[C:23]([C:24]([Cl:35])=[C:25]([O:31][CH2:32][CH2:33][CH3:34])[O:26][C:27]2=[O:28])=[CH:22][CH:21]=1)=[O:18])CC1C=CC=CC=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[C:36](N[C@H](C(N[C@H](C(NC1C=C2C(C(Cl)=C(OCCC)OC2=O)=CC=1)=O)C)=O)C)(=O)[C:37]1C=CC=C[CH:38]=1.C(N[C@H](C(NC1C=C2C(C(Cl)=C(OCC)OC2=O)=CC=1)=O)C(C)C)(OC(C)(C)C)=O.C(N[C@H](C(NC1C=C2C(C(Cl)=C(OCC)OC2=O)=CC=1)=O)C)(OC(C)(C)C)=O.C(N[C@H](C(NC1C=C2C(C(Cl)=C(OCCC3C=CC=CC=3)OC2=O)=CC=1)=O)C)(OC(C)(C)C)=O>>[C:1]([NH:8][C@H:9]([C:17]([NH:19][C:20]1[CH:30]=[C:29]2[C:23]([C:24]([Cl:35])=[C:25]([O:31][CH2:32][CH2:33][CH3:34])[O:26][C:27]2=[O:28])=[CH:22][CH:21]=1)=[O:18])[CH:37]([CH3:38])[CH3:36])([O:3][C:4]([CH3:7])([CH3:5])[CH3:6])=[O:2]

Participants

6

Reactant 5

HCID 22842420HCID 22842420, compoundHCID 22842421HCID 22842421, compoundHCID 22842423HCID 22842423, compoundHCID 22842424HCID 22842424, compoundHCID 70055269HCID 70055269, compound

Product 1

HCID 10411587HCID 10411587, compound

Procedure

7-(Boc-phenylalanyl)amino-4-chloro-3-propyloxyisocoumarin, 7-(benzoylalanylalanyl)amino-4-chloro-3-propyloxyisocoumarin, 7-(Boc-valyl)amino-4-chloro-3-ethoxyisocoumarin, 7-(Boc-alanyl)amino-4-chloro-3-ethoxyisocoumarin and 7-(Boc-alanyl)amino-4-chloro-3-(2-phenylethoxy)isocoumarin can be prepared by the same procedure.

Sources & evidence

ORD record
ord-e601a58b8c11463eba5613af3a1df08f
Source dataset
uspto-grants-1992_02
Patent number
US05089633

Reaction notes

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