Hydrogen Bromide → HCID 13588085, compound

Participants

Reaction Steps

A mixture of 7.5 parts of N-[1-(2-aminoethyl)-4-piperidinyl]-1-[(4-methoxyphenyl)methyl]-1H-benzimidazol-2-amine and 225 parts of a hydrobromic acid solution 48% in water was stirred and heated over week-end. After cooling, the precipitated product was filtered off and dried, yielding 7.3 parts (57%) of 4-[[2-[[1-(2-aminoethyl)-4-piperidinyl]amino]-1H-benzimidazol- 1-yl]methyl]phenol trihydrobromide monohydrate; mp.>250° C. (intermediate 139).

Provenance & Evidence