N-([1,3'-bipiperidin]-4-yl)-1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-amine → 1-[(4-fluorophenyl)methyl]-5-methoxy-N-[1-[2-(2-pyrimidinylamino)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine

HRID 1534744Notes

Reaction equation

HRID 1534744 reaction equation
C(O)(=O)/C=C/[C:4](O)=[O:5].[N:9]1[CH:14]=[CH:13][CH:12]=[N:11][C:10]=1[NH:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21](C2C3N=C(N)N(CC4N=CSC=4)C=3C=CC=2)[CH2:20][CH2:19]1.N1(C2CCCNC2)CCC([NH:46][C:47]2[N:51]([CH2:52][C:53]3[CH:58]=[CH:57][C:56]([F:59])=[CH:55][CH:54]=3)[C:50]3[CH:60]=[CH:61][CH:62]=[CH:63][C:49]=3[N:48]=2)CC1>>[F:59][C:56]1[CH:57]=[CH:58][C:53]([CH2:52][N:51]2[C:50]3[CH:60]=[CH:61][C:62]([O:5][CH3:4])=[CH:63][C:49]=3[N:48]=[C:47]2[NH:46][CH:21]2[CH2:20][CH2:19][N:18]([CH2:17][CH2:16][NH:15][C:10]3[N:9]=[CH:14][CH:13]=[CH:12][N:11]=3)[CH2:23][CH2:22]2)=[CH:54][CH:55]=1

Participants

3

Reactant 2

HCID 15614721N-([1,3'-bipiperidin]-4-yl)-1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-amineHCID 86745494[1-[2-(2-pyrimidinylamino)ethyl]-4-piperidinyl]-1-(4-thiazolylmethyl)-1H-benzimidazol-2-amine (E)-2-butenedioate

Product 1

HCID 135881771-[(4-fluorophenyl)methyl]-5-methoxy-N-[1-[2-(2-pyrimidinylamino)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine

Procedure

N-[[1-[2-(2-pyrimidinylamino)ethyl]-4-piperidinyl]-1-(4-thiazolylmethyl)-1H-benzimidazol-2-amine (E)-2-butenedioate (1:2); mp. 173.9° C. (compound 72);

Sources & evidence

ORD record
ord-101fa28597a44aeba50beb87b9008137
Source dataset
uspto-grants-1992_02
Patent number
USRE033833

Reaction notes

Loading…