HCID 9797987, compound → HCID 9974603, compound

HRID 1534802Notes

Reaction equation

HRID 1534802 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][C:14]3([C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH:18]=[CH:17]3)[CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:12][CH2:13][C:14]3([C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH2:18][CH2:17]3)[CH2:15][CH2:16]2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 9797987HCID 9797987, compound

Product 1

HCID 9974603HCID 9974603, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1'-((4-Methylphenyl)sulfonyl)spiro(1H-indene-1,4'-piperidine) (57.7 mg, 0.17 mmol), prepared as in example 2, was dissolved in absolute ethanol (4 ml), treated with 10% Palladium on carbon (14.2 mg), and hydrogenated at 40 psi, ambient temperature, for 3 hr. The mixture was filtered through Solka floc and the filtrate was evaporated to dryness in vacuo. The residue was crystallized from ether to provide the title compound: (m.p. 140°-142°).

Workup

  1. filtrationThe mixture was filtered through Solka floc
  2. customthe filtrate was evaporated to dryness in vacuo
  3. customThe residue was crystallized from ether

Sources & evidence

ORD record
ord-a72e76e766cb446a84a21ac86ac533e9
Source dataset
uspto-grants-1992_02
Patent number
US05091387

Reaction notes

Loading…