HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 19908258, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 1-Cyclopropyl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13825515 | — |
| Reactant | 1,2,3,4,5,6-Hexahydropyrrolo[3,4-c]pyrrole dihydrobromide | HCID 23282849 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 19908258 | HCID 19908258 | 74.4% |
Reaction Steps
0.6 g of 1-cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 1,2 g of 3,7-diazabicyclo[3.3.0]oct-1(5)-ene dihydrobromide and 1.3 ml of 1,8diazabicyclo[5.4.0]undec-7-ene (DBU) were suspended in 32 ml of acetonitrile and the suspension was refluxed for 10 hours. The reaction mixture was kept overnight at room temperature. The produced precipitate was filtered and washed with ethanol. 0.58 g of the titled compound was obtained (yield 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05091384 |
| Source dataset | uspto-grants-1992_02 |
| ORD ID | ord-365c3758552840258c9eb4a08185c1ed |
| Source note | uspto-grants-1992_02 |