HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 67940770, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | HCID 15189036 | HCID 15189036 | — |
| Reactant | 1,2,3,4,5,6-Hexahydropyrrolo[3,4-c]pyrrole dihydrobromide | HCID 23282849 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 67940770 | HCID 67940770 | 92% |
Reaction Steps
1-tert-Butyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.32 g), 3,7-diazabicyclo-[3.3.0] oct-1(5)-ene dihydrobromide (0.3 g) and 1,8-diazabicyclo [5.4.0] undec-7-ene (DBU, 0.55 ml) in acetonitrile (12 ml) was refluxed for 5 hours. The produced precipitate was collected by filtration, washed with acetonitrile and methanol to give the title compound (0.38 g, yield 92%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05091384 |
| Source dataset | uspto-grants-1992_02 |
| ORD ID | ord-0a68f1d0c0424db1941caa88ca9616af |
| Source note | uspto-grants-1992_02 |