Water → HCID 19810730, compound

HRID 1534848Notes

Reaction equation

HRID 1534848 reaction equation
C[O-].[Na+].[Cl:4][CH:5]([N:22]1[CH:26]=[N:25][CH:24]=[N:23]1)[C:6](Cl)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20])[C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1.O>CO>[Cl:4][CH:5]([N:22]1[CH:26]=[N:25][CH:24]=[N:23]1)[CH:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20])[C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 962WaterHCID 10942334Sodium MethoxideHCID 15096590HCID 15096590, compound

Product 1

HCID 19810730HCID 19810730, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5.4 g of sodium methylate are added to a solution of 17.8 g (0.0503 mol) of 1,2-dichloro-1-(1,2,4-triazol-1-yl)-2-(2-fluorophenyl)-2-(4-fluorophenyl)-ethane in 125 ml of methanol. After the reaction mixture has been refluxed for one hour, 100 ml of water are added to the solution, which is then extracted several times by shaking with methyl tert-butyl ether. The organic phase isolated is washed twice with water, dried over sodium sulfate and evaporated down, 15.5 g (97%) of 1-chloro-1-(1,2,4-triazol-1-yl)-2-(2-fluorophenyl)-2-(4-fluorophenyl)-ethane being obtained as a 1:1 E/Z mixture.

Workup

  1. temperatureAfter the reaction mixture has been refluxed for one hour
  2. extractionis then extracted several times
  3. customThe organic phase isolated
  4. washis washed twice with water
  5. dry with materialdried over sodium sulfate
  6. customevaporated down

Sources & evidence

ORD record
ord-d6f86bde9fb54a079282444059be3a27
Source dataset
uspto-grants-1992_02
Patent number
US05091401

Reaction notes

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