Benzophenone, 2',5-dichloro-2-methylamino- → 2',5-Dichloro-2-methylaminobenzhydrol

HRID 1534881Notes

Reaction equation

HRID 1534881 reaction equation
[BH4-].[Na+].[CH3:3][NH:4][C:5]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])=[O:8]>CO>[CH3:3][NH:4][C:5]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:6]=1[CH:7]([OH:8])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15]

Participants

4

Reactant 2

HCID 21833Benzophenone, 2',5-dichloro-2-methylamino-HCID 4311764Sodium borohydride

Product 1

HCID 124217352',5-Dichloro-2-methylaminobenzhydrol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

750 mg of sodium borohydride are added in individual portions to a suspension of 2.8 grams of 2-methylamino-2', 5-dichlorobenzophenone in 20 ml of methanol. After reaction for about ten minutes, the solvent is evaporated in a vacuum. After absorption in ether, washing with water, and then drying, 2-methylamino-2',5-dichlorobenzhydrol is isolated by crystallization (2.52 g).

Workup

  1. customAfter reaction for about ten minutes
  2. customthe solvent is evaporated in a vacuum
  3. customAfter absorption in ether
  4. washwashing with water
  5. customdrying

Sources & evidence

ORD record
ord-cde44cd488054cf1ae0575c8998676b2
Source dataset
uspto-grants-1992_02
Patent number
US05091415

Reaction notes

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