反应详情

250 mg (1.06 mmol) of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)propionic acid, ethyl ester (Alt-0027) and 400 mg (3.22 mmol) of 2-(2-aminoethyl)-1-methyl-pyrrole were heated together in a 10 ml round bottom flask with stirring (no solvent) at 110°-120° C. for 3.5 hours. The dark viscous residue was treated with a 1:1 mixture of ether/acetone and stirred vigorously for 30 minutes. The precipitate was collected by filtration and was washed with ether and acetone and dried in vacuo to yield 265 mg of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-N-[2-(1-methylpyrrol-2-yl)ethyl] propanamide (AIT-0035) as an off-white solid. Yield: 80%

1. stirringstirred vigorously for 30 minutes
2. filtrationThe precipitate was collected by filtration
3. washwas washed with ether and acetone
4. customdried in vacuo