反应详情

0.565 g (4.41 mmol) of 2-(2-aminoethyl)-1-methylpyrrolidine was added to a 10 ml round bottom flask equipped with a magnetic stirring bar. The solution was heated and 0.250 g (1.06 mmol) of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)propionic acid, ethyl ester (AIT-0027) was added and the solution was heated at 110°-120° C. for two hours. The orange solution was allowed to cool to room temperature and 8 ml acetonitrile was added and the solution was stirred for 20 minutes to wash the solid. The solution was filtered by Buchner vacuum filtration and the solid was washed with acetonitrile and then with ether. Upon drying 265 mg of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]propanamide (AIT-0045) as a white solid was obtained.

1. customequipped with a magnetic stirring bar
2. temperatureThe solution was heated
3. temperaturethe solution was heated at 110°-120° C. for two hours
4. washto wash the solid
5. filtrationThe solution was filtered by Buchner vacuum filtration
6. washthe solid was washed with acetonitrile
7. dry with materialUpon drying 265 mg of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]propanamide (AIT-0045) as a white solid
8. customwas obtained