Acetonitrile → HCID 136403356, compound

Participants

Reaction Conditions

Reaction Steps

0.516 g (5.05 mmol) of N-acetylethylenediamine was placed into a 10 ml round bottom flask. The flask was heated to 120° C. and 0.250 g (1.06 mmol) of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)propionic acid, ethyl ester (AIT-0027) was added to the stirring solution. The solution was heated at 120° C. for one hour. 8 ml of acetonitrile was added to the viscous oil and stirred. Approximately 1 ml of methanol was added and the solution was stirred vigorously for 30 minutes. The resulting white precipitate was collected by vacuum filtration and was washed with acetonitrile and ether to yield 237 mg of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-N-[2-[(1-oxoethyl)amino]ethyl]propanamide (AIT-0051) as a white solid upon drying. Yield: 76%

Provenance & Evidence