N-(2-Aminoethyl)piperidine → HCID 135992596, compound

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Reaction Steps

0.500 g (3.90 mmol) of 1-(2-aminoethyl)piperidine was added to a 10 ml round bottom flask equipped with a magnetic stirring bar. The amine was heated to 100°-110° C. and 0.250 g (1.06 mmol) of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)propionic acid, ethyl ester (AIT-0027) was added to the stirring solution. The solution was heated for one hour at which time it had solidified. The solution was allowed to cool to room temperature and 10 ml of acetonitrile was added to the solid. This mixture was stirred and the solid was collected by Buchner vacuum filtration. The white crystalline solid was washed with acetonitrile and then with ether to yield 290 mg of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-N-[[2-(1-piperidinyl)]ethyl]propanaide (AIT-0070). Yield: 86%.

Provenance & Evidence