反应详情

0.250 g (1.06 mmol) of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)propionic acid, ethyl ester (AIT-0027) was added to 1.85 g (25.0 mmol) of 1,3-diaminopropane in a 10 ml round bottom flask equipped with a magnetic stirring bar. The solution was stirred at room temperature for two hours. 10 ml ether was added and the solution was stirred for a few minutes. The ether solution was decanted, leaving an oil residue. 5 ml of acetonitrile and 4 ml of ether were added and the solution was stirred. Methanol was added dropwise until a precipitate had formed. The solution was filtered and washed with acetonitrile and ether, to yield 205 mg of 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-N-(3-aminopropyl)propanamide (AIT-0074). m.p. 172°-175° C. Yield: 73%

1. customequipped with a magnetic stirring bar
2. stirringthe solution was stirred for a few minutes
3. customThe ether solution was decanted
4. customleaving an oil residue
5. stirringthe solution was stirred
6. customhad formed
7. filtrationThe solution was filtered
8. washwashed with acetonitrile and ether