Imidazole → HCID 19908895, compound

Participants

Reaction Steps

A mixture of cyclohexene oxide (Va) (9.81 g), ethanol (25 ml) and imidazole (13.6 g) was refluxed under heating for 70 hours and the ethanol is removed by evaporation. After addition of a small amount of water, the residue was extracted with chloroform. The extract was washed with a saturated aqueous solution of sodium chloride, dried and evaporated to give 2-imidazolylcyclohexanol (IVa) (12.7 g) as crystaline residue (yield 76%). Mp. 133°-134° C. NMR: δ (CDCl3) 1.3-2.2m8H, 3.6m2H, 4.86s1H, 6.83s1H, 6.89s1H, 7.30s1H ppm.

Provenance & Evidence