1-Propanol, 3-amino-2,2-dimethyl- → 3-{4-[8-Cyclopropylmethyl-2-(4-fluorophenyl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-ylamino}-2,2-dimethylpropan-1-ol

HRID 153500Notes

Reaction equation

HRID 153500 reaction equation
[CH:1]1([CH2:4][c:5]2[c:6]3[n:7]([cH:8][cH:9][n:10]2)[c:11](-[c:21]2[n:22][c:23]([S:27]([CH3:28])(=[O:29])=[O:30])[n:24][cH:25][cH:26]2)[c:12](-[c:14]2[cH:15][cH:16][c:17]([F:20])[cH:18][cH:19]2)[n:13]3)[CH2:2][CH2:3]1.[NH2:31][CH2:32][C:33]([CH2:34][OH:35])([CH3:36])[CH3:37]>>[CH:1]1([CH2:4][c:5]2[c:6]3[n:7]([cH:8][cH:9][n:10]2)[c:11](-[c:21]2[n:22][c:23]([NH:31][CH2:32][C:33]([CH2:34][OH:35])([CH3:36])[CH3:37])[n:24][cH:25][cH:26]2)[c:12](-[c:14]2[cH:15][cH:16][c:17]([F:20])[cH:18][cH:19]2)[n:13]3)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 1173261-Propanol, 3-amino-2,2-dimethyl-HCID 588695518-Cyclopropylmethyl-2-(4-fluorophenyl)-3-(2-methanesulfonylpyrimidin-4-yl)imidazo[1,2-a]pyrazine

Product 1

HCID 160504493-{4-[8-Cyclopropylmethyl-2-(4-fluorophenyl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-ylamino}-2,2-dimethylpropan-1-ol

Sources & evidence

ORD record
ord-b4c6dbf050c641b494eac52771da25cf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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