(4S)-2,8-Dimethyl-4-[(toluenesulfonyl)amino]-5-nonanone → (4S)-2,8-Dimethyl-5-hydroxy-4-[(toluenesulfonyl)amino]-5-vinylnonane

関与物質

反応手順

To a stirred 0° C. solution of the resultant compound of Example 7 (79 mg, 0.23 mmol) in dry THF (8 mL) was added vinyl magnesium bromide (1.5 mL of a 1.0 M solution in THF) dropwise. The mixture was warmed (room temperature, 10 hours), quenched (8 mL H2O+2 mL brine), acidified with 0.1M H3PO4 (pH=7), and extracted with ether (3×4 mL). The combined ether phase was washed (4 mL brine), dried (Na2SO4), filtered, and evaporated to give 81 mg (95%) of the desired product as a 4:1 mixture of diastereomers.

情報源と証拠