Pyridine → Azd-1656 racemate

HRID 1535096Notes

Reaction equation

HRID 1535096 reaction equation
[Cl:1][C:2]([N:3]([CH3:4])[CH3:5])=[C:6]([CH3:7])[CH3:8].[Cl:51][CH2:52][Cl:53].[N:9]1([C:13](=[O:14])[c:15]2[n:16][cH:17][c:18]([O:21][c:22]3[cH:23][c:24]([C:25](=[O:26])[OH:27])[cH:28][c:29]([O:31][CH:32]([CH2:33][O:34][CH3:35])[CH3:36])[cH:30]3)[n:19][cH:20]2)[CH2:10][CH2:11][CH2:12]1.[NH2:37][c:38]1[n:39][cH:40][c:41]([CH3:44])[n:42][cH:43]1.[cH:45]1[cH:46][cH:47][n:48][cH:49][cH:50]1>>[N:9]1([C:13](=[O:14])[c:15]2[n:16][cH:17][c:18]([O:21][c:22]3[cH:23][c:24]([C:25](=[O:27])[NH:37][c:38]4[n:39][cH:40][c:41]([CH3:44])[n:42][cH:43]4)[cH:28][c:29]([O:31][CH:32]([CH2:33][O:34][CH3:35])[CH3:36])[cH:30]3)[n:19][cH:20]2)[CH2:10][CH2:11][CH2:12]1

Participants

6

Reactant 5

HCID 1049PyridineHCID 6344DichloromethaneHCID 3132155-Methylpyrazin-2-amineHCID 6407921-Chloro-N,N-2-trimethylpropenylamineHCID 674881383-[5-(Azetidine-1-carbonyl)pyrazin-2-yl]oxy-5-(1-methoxypropan-2-yloxy)benzoic acid

Product 1

HCID 73224028Azd-1656 racemate

Sources & evidence

ORD record
ord-94fa9dbb2613487cb78da734cbc82d0c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…