5-Fluoro-2,3-dihydro-1H-inden-1-amine → 7-chloro-6-[1-(3-chloro-4-fluoro-phenyl)-ethylamino]-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

HRID 1535099Notes

Reaction equation

HRID 1535099 reaction equation
[Cl:1][c:2]1[c:3]([O:19][S:20]([C:21]([F:22])([F:23])[F:24])(=[O:25])=[O:26])[c:4]2[c:5]([cH:17][cH:18]1)[CH2:6][CH2:7][N:8]([C:11]([C:12]([F:13])([F:14])[F:15])=[O:16])[CH2:9][CH2:10]2.[Cl:27][c:28]1[cH:29][c:30]([CH:35]([CH3:36])[NH2:37])[cH:31][cH:32][c:33]1[F:34].[F:38][c:39]1[cH:40][c:41]2[c:42]([cH:43][cH:44]1)[CH:45]([NH2:46])[CH2:47][CH2:48]2>>[Cl:1][c:2]1[c:3]([NH:37][CH:35]([c:30]2[cH:29][c:28]([Cl:27])[c:33]([F:34])[cH:32][cH:31]2)[CH3:36])[c:4]2[c:5]([cH:17][cH:18]1)[CH2:6][CH2:7][N:8]([C:11]([C:12]([F:13])([F:14])[F:15])=[O:16])[CH2:9][CH2:10]2

Participants

4

Reactant 3

HCID 166663285-Fluoro-2,3-dihydro-1H-inden-1-amineHCID 18543184(-)-3-Chloro-4-fluoro-α-methylbenzenemethanamineHCID 574477477-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethylsulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 866296267-chloro-6-[1-(3-chloro-4-fluoro-phenyl)-ethylamino]-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Sources & evidence

ORD record
ord-1782a88f64ce47e4a4d4e9926bac79dd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…