2-Isopropoxyphenylboronic acid → 2-Chloro-8-(2-isopropoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

HRID 1536119Notes

Reaction equation

HRID 1536119 reaction equation
[Br:1][c:2]1[c:3]2[n:4]([cH:5][cH:6][cH:7]1)[n:8][c:9]([Cl:11])[n:10]2.[C:25]([O:26][C:27]([N:28]1[CH2:29][CH2:30][c:31]2[cH:32][cH:33][c:34]([NH2:35])[cH:36][c:37]2[CH2:38][CH2:39]1)=[O:40])([CH3:41])([CH3:42])[CH3:43].[CH:12]([CH3:13])([CH3:14])[O:15][c:16]1[c:17]([B:22]([OH:23])[OH:24])[cH:18][cH:19][cH:20][cH:21]1.[CH:44]1([P:45]([CH:46]2[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51]2)[c:52]2[cH:53][cH:54][cH:55][cH:56][c:57]2-[c:58]2[cH:59][cH:60][cH:61][cH:62][c:63]2[P:64]([CH:65]2[CH2:66][CH2:67][CH2:68][CH2:69][CH2:70]2)[CH:71]2[CH2:72][CH2:73][CH2:74][CH2:75][CH2:76]2)[CH2:77][CH2:78][CH2:79][CH2:80][CH2:81]1>>[c:2]1(-[c:17]2[c:16]([O:15][CH:12]([CH3:13])[CH3:14])[cH:21][cH:20][cH:19][cH:18]2)[c:3]2[n:4]([cH:5][cH:6][cH:7]1)[n:8][c:9]([Cl:11])[n:10]2

Participants

5

Reactant 4

HCID 50840992-Isopropoxyphenylboronic acidHCID 11402789Tert-butyl 7-amino-4,5-dihydro-1H-benzo[D]azepine-3(2H)-carboxylateHCID 249469872,2'-Bis(dicyclohexylphosphino)-1,1'-biphenylHCID 674813708-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 674814482-Chloro-8-(2-isopropoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

Sources & evidence

ORD record
ord-8a751167a3494bcb99e1fd653630d54f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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