Acetone → 6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3-(2-methanesulfonyl-ethyl)-3H-benzoimidazole-5-carbaldehyde

HRID 1537079Notes

Reaction equation

HRID 1537079 reaction equation
[Br:1][c:2]1[cH:3][c:4]([Cl:27])[c:5]([NH:8][c:9]2[c:10]([CH2:25][OH:26])[cH:11][c:12]3[c:13]([n:14][cH:15][n:16]3[CH2:17][CH2:18][S:19](=[O:20])(=[O:21])[CH3:22])[c:23]2[F:24])[cH:6][cH:7]1.[CH3:31][C:32](=[O:33])[CH3:34].[O:28]=[Mn:29]=[O:30]>>[Br:1][c:2]1[cH:3][c:4]([Cl:27])[c:5]([NH:8][c:9]2[c:10]([CH:25]=[O:26])[cH:11][c:12]3[c:13]([n:14][cH:15][n:16]3[CH2:17][CH2:18][S:19](=[O:20])(=[O:21])[CH3:22])[c:23]2[F:24])[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 180AcetoneHCID 14801Manganese dioxideHCID 21114203[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3-(2-methanesulfonyl-ethyl)-3H-benzoimidazol-5-yl]-methanol

Product 1

HCID 211142046-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3-(2-methanesulfonyl-ethyl)-3H-benzoimidazole-5-carbaldehyde

Sources & evidence

ORD record
ord-51aa06a1086c47ecba3f000560cd7ff4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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