Ammonia → N-{3-[5-(2-amino-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-chlorophenyl}-2,6-difluorobenzenesulfonamide

HRID 1537698Notes

Reaction equation

HRID 1537698 reaction equation
[CH3:39][OH:40].[Cl:1][c:2]1[c:3]([NH:26][S:27](=[O:28])(=[O:29])[c:30]2[c:31]([F:37])[cH:32][cH:33][cH:34][c:35]2[F:36])[cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]([CH:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[s:11][c:12]1-[c:13]1[n:14][c:15]([Cl:19])[n:16][cH:17][cH:18]1.[NH3:38]>>[Cl:1][c:2]1[c:3]([NH:26][S:27](=[O:28])(=[O:29])[c:30]2[c:31]([F:37])[cH:32][cH:33][cH:34][c:35]2[F:36])[cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]([CH:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[s:11][c:12]1-[c:13]1[n:14][c:15]([NH2:38])[n:16][cH:17][cH:18]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 57989796N-{2-Chloro-3-[5-(2-chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Product 1

HCID 57989886N-{3-[5-(2-amino-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-chlorophenyl}-2,6-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-6dd6df53db3341d89c9d3f228b672cc8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…