1-Hydroxy-1-cyclopropanecarboxylic acid → N-[1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-1-hydroxycyclopropane-1-carboxamide

HRID 153775Notes

Reaction equation

HRID 153775 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5](-[n:8]2[n:9][cH:10][c:11]3[cH:12][c:13]([O:17][CH:18]([CH:19]([CH3:20])[NH2:21])[c:22]4[cH:23][cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]4)[cH:14][cH:15][c:16]23)[cH:6][cH:7]1.[OH:32][C:33]1([C:36](=[O:37])[OH:38])[CH2:34][CH2:35]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[n:8]2[n:9][cH:10][c:11]3[cH:12][c:13]([O:17][CH:18]([CH:19]([CH3:20])[NH:21][C:36]([C:33]4([OH:32])[CH2:34][CH2:35]4)=[O:37])[c:22]4[cH:23][cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]4)[cH:14][cH:15][c:16]23)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 27331601-Hydroxy-1-cyclopropanecarboxylic acidHCID 690920211-[1-(4-Fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-amine

Product 1

HCID 72258703N-[1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-1-hydroxycyclopropane-1-carboxamide

Sources & evidence

ORD record
ord-9d5646a532b041d98c4603c6a6aa0ae1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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