3-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chloride → tert-Butyl {4-[(5-bromo-2-methoxy-benzyl)-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-cyclohexyl}-methyl-carbamate

HRID 1537755Notes

Reaction equation

HRID 1537755 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([O:25][CH3:26])[c:6]([CH2:7][NH:8][CH:9]2[CH2:10][CH2:11][CH:12]([N:15]([C:16]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])[CH3:23])[CH2:13][CH2:14]2)[cH:24]1.[Cl:27][c:28]1[c:29]2[c:30]([s:31][c:32]1[C:33](=[O:34])[Cl:35])[c:36]([F:41])[cH:37][cH:38][c:39]2[F:40]>>[Br:1][c:2]1[cH:3][cH:4][c:5]([O:25][CH3:26])[c:6]([CH2:7][N:8]([CH:9]2[CH2:10][CH2:11][CH:12]([N:15]([C:16]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])[CH3:23])[CH2:13][CH2:14]2)[C:33]([c:32]2[c:28]([Cl:27])[c:29]3[c:30]([s:31]2)[c:36]([F:41])[cH:37][cH:38][c:39]3[F:40])=[O:34])[cH:24]1

Participants

3

Reactant 2

HCID 219384153-Chloro-4,7-difluorobenzo[b]thiophene-2-carbonyl chlorideHCID 59683581tert-Butyl [4-(5-bromo-2-methoxy-benzylamino)-cyclohexyl]-methyl-carbamate

Product 1

HCID 59683556tert-Butyl {4-[(5-bromo-2-methoxy-benzyl)-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-cyclohexyl}-methyl-carbamate

Sources & evidence

ORD record
ord-f772a1bfa64f4df4a208923386955752
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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