Sodium ion → 6-[2-fluoro-5-[1-(4-methylsulfonylpiperazin-1-yl)ethyl]-3-pyridinyl]-N,N-bis[(4-methoxyphenyl)methyl]-2-methylpyrimidin-4-amine

HRID 1537760Notes

Reaction equation

HRID 1537760 reaction equation
[CH3:42][S:43]([Cl:44])(=[O:45])=[O:46].[Cl:49][CH2:50][Cl:51].[F:1][c:2]1[n:3][cH:4][c:5]([CH:34]([CH3:35])[N:36]2[CH2:37][CH2:38][NH:39][CH2:40][CH2:41]2)[cH:6][c:7]1-[c:8]1[cH:9][c:10]([N:15]([CH2:16][c:17]2[cH:18][cH:19][c:20]([O:23][CH3:24])[cH:21][cH:22]2)[CH2:25][c:26]2[cH:27][cH:28][c:29]([O:32][CH3:33])[cH:30][cH:31]2)[n:11][c:12]([CH3:14])[n:13]1.[Na+:48].[OH-:47]>>[F:1][c:2]1[n:3][cH:4][c:5]([CH:34]([CH3:35])[N:36]2[CH2:37][CH2:38][N:39]([S:43]([CH3:42])(=[O:45])=[O:46])[CH2:40][CH2:41]2)[cH:6][c:7]1-[c:8]1[cH:9][c:10]([N:15]([CH2:16][c:17]2[cH:18][cH:19][c:20]([O:23][CH3:24])[cH:21][cH:22]2)[CH2:25][c:26]2[cH:27][cH:28][c:29]([O:32][CH3:33])[cH:30][cH:31]2)[n:11][c:12]([CH3:14])[n:13]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 961HydroxideHCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 178491056HCID 178491056, compound

Product 1

HCID 1784910606-[2-fluoro-5-[1-(4-methylsulfonylpiperazin-1-yl)ethyl]-3-pyridinyl]-N,N-bis[(4-methoxyphenyl)methyl]-2-methylpyrimidin-4-amine

Sources & evidence

ORD record
ord-2812f5051d0448b7ba752ba875a7ccc2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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