3-(4-chloro-5-fluoro-2-hydroxyphenyl)-1-pentyl-1,3-dihydro-2H-indol-2-one → 3-(4-chloro-5-fluoro-2-hydroxyphenyl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-one

HRID 1538228Notes

Reaction equation

HRID 1538228 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:6][c:7]2[c:8]1[CH:9]([c:10]1[c:11]([OH:12])[cH:13][c:14]3[c:19]([cH:20]1)[O:18][CH2:17][O:15]3)[C:5](=[O:16])[N:21]2[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].[Cl:27][c:28]1[cH:29][c:30]([OH:50])[c:31]([CH:35]2[C:36](=[O:49])[N:37]([CH2:44][CH2:45][CH2:46][CH2:47][CH3:48])[c:38]3[cH:39][cH:40][cH:41][cH:42][c:43]32)[cH:32][c:33]1[F:34]>>[CH2:5]([OH:16])[C:35]1([c:31]2[c:30]([OH:50])[cH:29][c:28]([Cl:27])[c:33]([F:34])[cH:32]2)[C:36](=[O:49])[N:37]([CH2:44][CH2:45][CH2:46][CH2:47][CH3:48])[c:38]2[cH:39][cH:40][cH:41][cH:42][c:43]21

Participants

3

Reactant 2

HCID 120043073-(4-chloro-5-fluoro-2-hydroxyphenyl)-1-pentyl-1,3-dihydro-2H-indol-2-oneHCID 588725004-bromo-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 588725043-(4-chloro-5-fluoro-2-hydroxyphenyl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-one

Sources & evidence

ORD record
ord-33fbf4f70ca54c7aab54f42c9befaea0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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