HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonic Acid → Clopidogrel Besylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonic Acid | HCID 7371 | — |
| Reactant | Clopidogrel | HCID 60606 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Clopidogrel Besylate | HCID 9847991 | — |
Reaction Steps
Clopidogrel base was dissolved in acetone to obtain a clear solution. Then benzenesulfonic acid was added to the solution at 20° C. The reaction mixture was heated to reflux temperature for 2 to 10 hrs. The solvent was evaporated to dryness under reduced pressure to obtain the title salt as a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732608B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-cd6d5f6145844cd3830a94afe5ddc86d |
| Source note | uspto-grants-2010_06 |