Ethanol → Ethyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

HRID 1538489Notes

Reaction equation

HRID 1538489 reaction equation
[CH3:17][CH2:18][OH:19].[OH-:20].[OH-:22].[OH:1][C:2]1([CH2:13][N+:14]([O-:15])=[O:16])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][CH2:11][CH3:12])[CH2:6][CH2:7]1.[Pd+2:21]>>[OH:1][C:2]1([CH2:13][NH2:14])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][CH2:11][CH3:12])[CH2:6][CH2:7]1

Participants

5

Reactant 4

HCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 22708806Ethyl 4-hydroxy-4-(nitromethyl)-1-piperidinecarboxylate

Product 1

HCID 14049029Ethyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-db7bd69134b2482daf5465af54213682
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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