反应详情

Clopidogrel base was dissolved in methanol to obtain a clear solution. Benzenesulfonic acid was added to the solution at 20° C. The reaction mixture was heated to reflux temperature for 2 to 10 hrs. The solvent was evaporated to dryness under reduced pressure to obtain the title compound.

1. customto obtain a clear solution
2. temperatureThe reaction mixture was heated
3. temperatureto reflux temperature for 2 to 10 hrs
4. customThe solvent was evaporated to dryness under reduced pressure