Acetone → ethyl 2-[(trans-4-{6-[(2'-cyano-3-fluorobiphenyl-4-yl)methyl]-5-oxo-7-propyl[1,2,4]triazolo[1,5-a]pyrimidin-4(5H)-yl}cyclohexyl)oxy]-4-hydroxybutanoate
Reaction equation
[C:1](#[N:2])[c:3]1[c:4](-[c:9]2[cH:10][c:11]([F:45])[c:12]([CH2:15][c:16]3[c:17](=[O:44])[n:18]([CH:28]4[CH2:29][CH2:30][CH:31]([O:34][CH:35]([C:36](=[O:37])[O:38][CH2:39][CH3:40])[CH2:41][CH:42]=[CH2:43])[CH2:32][CH2:33]4)[c:19]4[n:20]([c:21]3[CH2:22][CH2:23][CH3:24])[n:25][cH:26][n:27]4)[cH:13][cH:14]2)[cH:5][cH:6][cH:7][cH:8]1.[CH3:52][C:53](=[O:54])[CH3:55].[CH3:56][C:57]#[N:58].[I+3:46]([O-:47])([O-:48])([O-:49])[O-:50].[Na+:51].[OH2:64].[Os:59](=[O:60])(=[O:61])(=[O:62])=[O:63]>>[C:1](#[N:2])[c:3]1[c:4](-[c:9]2[cH:10][c:11]([F:45])[c:12]([CH2:15][c:16]3[c:17](=[O:44])[n:18]([CH:28]4[CH2:29][CH2:30][CH:31]([O:34][CH:35]([C:36](=[O:37])[O:38][CH2:39][CH3:40])[CH2:41][CH2:42][OH:47])[CH2:32][CH2:33]4)[c:19]4[n:20]([c:21]3[CH2:22][CH2:23][CH3:24])[n:25][cH:26][n:27]4)[cH:13][cH:14]2)[cH:5][cH:6][cH:7][cH:8]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-505bc1a38e3444ec81b963519f2a2997
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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