反应详情

Clopidogrel base was dissolved in methanol. Benzene sulphonic acid was added to the solution at 20° C. The reaction mixture was heated to reflux temperature for 2 hrs. The solution was cooled to room temperature and was added drop-wise to diethyl ether. The suspension was stirred at RT. The solid was filtered and dried in a vacuum oven to give Clopidogrel besylate, similar to that obtained above.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux temperature for 2 hrs
3. filtrationThe solid was filtered
4. customdried in a vacuum oven