反应详情

Clopidogrel base was dissolved in methanol. Benzene sulphonic acid was added to the solution at 20° C. The reaction mixture was heated to reflux temperature for 2 hrs. The solution was cooled to room temperature and the methanolic solution was added drop-wise to the boiling toluene. The resulting solution was refluxed for an additional 20 minutes. The solution was cooled to room temperature and was stirred at this temperature for extended hours. The solvent was evaporated under reduced pressure to dryness to obtain Clopidogrel besylate, similar to that obtained above.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux temperature for 2 hrs
3. temperatureThe resulting solution was refluxed for an additional 20 minutes
4. temperatureThe solution was cooled to room temperature
5. customThe solvent was evaporated under reduced pressure to dryness